An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (Mpro) of SARS-COV-2 from crude natural extractsArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis applied approach baicalein binding carried catalytic characteristic Chinese complementary complex Compound Covalent binder Cys145 database drug target electrophilic Final functional HIS163 HIS164 His41 independent inhibitor inhibitors Ion knowledge M pro M(pro) mass mass spectrometry maturation metabolomic metabolomics Michael molecular dynamics MPro nucleophilic peptide platform polyprotein protease protein-ligand Proteins proteomic proteomics residue SARS-CoV-2 SARS-CoV-2. Scutellaria baicalensis tested the SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123824 PMC 바로가기
Comparison of COVID-19 pneumonia during the SARS-CoV-2 Omicron wave and the previous non-Omicron wave in a single facilityArticle Published on 2022-11-012022-11-16 Journal: Respiratory investigation [Category] SARS, 변종, [키워드] acute respiratory syndrome addition caused characteristic Characteristics Chest CT Cluster-like ground-glass opacities Computed tomography consolidation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 described disease distribution enrolled evaluated GGO GGOs ground-glass opacity groups hospital omicron Omicron variant other variants patients with COVID-19 Pneumonia pneumonia. predominant Prevalence random replicate significantly lower the SARS-CoV-2 variant variants [DOI] 10.1016/j.resinv.2022.08.001 PMC 바로가기
Ganoderma microsporum immunomodulatory protein acts as a multifunctional broad-spectrum antiviral against SARS-CoV-2 by interfering virus binding to the host cells and spike-mediated cell fusionArticle Published on 2022-11-012022-11-15 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2-expressing cells acute respiratory syndrome alleviate Antiviral binding blocked Broad-spectrum antiviral against SARS-CoV-2 caused Cell Cell fusion cell lines cell-free virus cells characteristic coronavirus Delta determine Diseases downregulation Effect evaluated examined flow cytometry fluorescence microscopy fluorescent Fungal immunomodulatory proteins fusion GMI HEK293T cell host cell immunomodulatory immunoprecipitation in vitro Infection Infectivity ingredient inhibit inhibited inhibitor Interaction investigated less mechanism multifunctional omicron Protein pseudotyped virus reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection SARS-CoV-2 spike protein SARS-CoV-2 variant spike mutation spike variant spike variants Strains Viral binding. virus were used [DOI] 10.1016/j.biopha.2022.113766 PMC 바로가기
Influence of COVID-19 pandemic on the decision making of patients in undergoing gamma knife radiosurgeryArticle Published on 2022-10-292022-11-16 Journal: European Journal of Medical Research [Category] 변종, [키워드] affected age analyses analyzed approach approval attenuate characteristic co-morbidity collected Comorbidity control group COVID-19 COVID-19 pandemic COVID-19 vaccination database decision Decision making Diagnosis Follow-up Frequency Gamma Gamma knife influence lesion lesions less MRI neurological Neurological deficit pandemic parameter Patient patients treated performance proportion Radiation Radiation dose Radiosurgery Sex status time interval treated Treatment vaccination vaccination. variant Volume [DOI] 10.1186/s40001-022-00859-w PMC 바로가기
Genomic Epidemiology and Serology Associated with a SARS-CoV-2 R.1 Variant Outbreak in New JerseyArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome antibody antibody resistance attack rate B.1.351 B.1.526 Care caused characteristic Clinical use collected Community Complete coronavirus COVID-19 Critical E484K mutation Evidence Examining exhibit exhibited hcp Health highlight individual infected individuals Infection Inpatient Lineage loss of activity monoclonal antibody Mutation N-terminal domain neutralization capacity Neutralizing antibody response neutralizing capacity New nosocomial NTD outbreak P.1 Patient plasma positive professional professionals proportion pseudovirus psychiatric facility Receptor binding domain reported reverse transcription robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sera Spike protein Symptom symptomatic COVID-19 disease tested the SARS-CoV-2 the United State treat vaccinated individual vaccinated individuals vaccination Vaccine variant variants of concern variants of concern. VOCs wild type [DOI] 10.1128/mbio.02141-22 PMC 바로가기
Emergence and Spread of the SARS-CoV-2 Variant of Concern Delta across Different Brazilian RegionsArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] affected analysis B.1.617.2 Bayesian method Brazil characteristic clade Cluster Combination Complete concern country COVID-19 COVID-19 pandemic Delta delta variant dissemination distribution dominant variant emergence Epidemic epidemiological Evolution fraction Genome genomic India likelihood Lineage outbreak pandemic Prevalence prevalent profiles Region regions remained Rio de Janeiro SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant spatiotemporal Stage subject Surveillance the SARS-CoV-2 transmission cluster variant Variant of concern. viral variant VoC [DOI] 10.1128/spectrum.02641-21 PMC 바로가기
Differential Infectivity of Original and Delta Variants of SARS-CoV-2 in Children Compared to AdultsArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome Adults age aliquot B.1.617.2 Canada characteristic children circulating circulating SARS-CoV-2 variants coronavirus COVID-19 Culture cycle threshold Delta delta variant demographics determine dose driver implicated in viral Infection infectious titers infective Infectivity mechanism Mutation Nasopharyngeal swab nasopharyngeal swab sample original pediatric positive predominant provided RT-PCR SARS-CoV-2 SARS-CoV-2 RT-PCR screened statistical analysis susceptible TCID TCID50 TCID50. tissue Transmission variant variants of concern variety Viral RNA VoC [DOI] 10.1128/spectrum.00395-22 PMC 바로가기
Diagnostic performance of corona virus disease 2019 chest computer tomography image recognition based on deep learning: Systematic review and meta-analysisArticle Published on 2022-10-212022-11-15 Journal: Medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy article articles assist AUROC authors characteristic Chest chest computer tomography China Cochrane Library combating country COVID-19 COVID-19 pandemic COVID-19 patient deep learning defined demographics Diagnosis diagnostic Final healthy highest inception inclusion criteria individual Infrastructure likelihood ratio Meta-analysis non-infected Odds ratio outcome Patient patients Pneumonia positive Predictive produced radiologist Research researcher resolved ROC Sample size screened searched secondary sensitivity Sensitivity and specificity specificity subgroup suspected patient Symptoms Virus Disease Web of Science [DOI] 10.1097/MD.0000000000031346 PMC 바로가기
A Comparative Study of Asymptomatic Malaria in a Forest Rural and Depleted Forest Urban Setting during a Low Malaria Transmission and COVID-19 Pandemic PeriodArticle Published on 2022-10-152022-11-15 Journal: BioMed Research International [Category] 치료기술, 치료제, [키워드] 95% CI activity Antigen Asymptomatic characteristic Community Comparative COVID-19 COVID-19 pandemic Depleted determine ecological enrolled expected forest Intervention logistic regression models malaria morbidity and mortality multivariate model Odds ratio participant Participants Period Plasmodium falciparum positive predictor Prevalence questionnaire Randomly Risk factors setting socio-demographic statistically significant Transmission urban was performed zone [DOI] 10.1155/2022/2545830 PMC 바로가기
Quantifying Mutational Response to Track the Evolution of SARS-CoV-2 Spike Variants: Introducing a Statistical-Mechanics-Guided Machine Learning MethodArticle Published on 2022-10-132022-11-16 Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종, [키워드] accompanied Affect analysis approach average binary classification model characteristic concern Critical database defined Evolution function global public health help identify implication information interest machine learning Mutation mutations pathogenicity predict residue response SARS-CoV-2 sequence spike spike glycoprotein Stage statistical track variant virus VoC VOCs VOIs [DOI] 10.1021/acs.jpcb.2c04574 PMC 바로가기